The success of transplantation relies on the compassion and generosity of donor families. Most recipients received their life-saving gift after the death of a stranger. Grief perspectives related to donation customarily revolve around the donor family. A less explored frontier is how the death impacts the transplant recipient, a second chance of life “at the expense of another’s death.” Watch Gift of Life Donor Program's Jacqui Kates and grateful liver recipient Peter Matthews for an exploration of survivor's guilt and transplant.